What are the side effects of Lomotil


  • Generic name: diphenoxylate and atropine
  • Brand Name: Lomotil
Lomotil Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What is Lomotil?

Lomotil (diphenoxylate and atropine) is a combined anti-diarrhea and anticholinergic drug used to treat diarrhea. Lomotil is available in generic form.

Common side effects of Lomotil are:

  • Sleepiness,
  • Dizziness,
  • A headache,
  • Fatigue,
  • Restlessness,
  • blurred vision,
  • dry mouth,
  • Nausea,
  • Vomiting
  • Stomach problems,
  • Loss of appetite,
  • Rash, or
  • Itching.

Tell your doctor if you experience any unlikely but serious side effects from Lomotil, including:

  • Stomach or abdominal pain or swelling,
  • severe nausea or vomiting,
  • mental / mood changes (e.g. mix-up, depression) or
  • Numbness and tingling of arms or legs.

What is Lomotil?

Dosage for Lomotil

The recommended starting dose for adults is two Lomotil tablets four times a day or 10 ml (two normal teaspoons) of Lomotil liquid (20 mg per day) four times a day. The pediatric dose is determined by the child's weight.

Which drugs, substances or dietary supplements interact with Lomotil?

Lomotil can interact with barbiturates or MAO inhibitors. Lomotil can interact with other drugs. Let your doctor know about all prescription and over-the-counter drugs and supplements you use.

Cyclopentolate hydrochloride eye solution usp 1

Lomotil during pregnancy and breastfeeding

During pregnancy, Lomotil should only be used if prescribed. This drug passes into breast milk. Ask your doctor before breastfeeding.

additional information

Our Lomotil (Diphenoxylate and Atropine) Side Effects Drug Center provides a comprehensive overview of the drug information available about the possible side effects of taking this drug.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Oxycodone 30 mg price per pill
Lomotil consumer information

Get emergency medical help if you have Signs of an allergic reaction : Beehives; Difficulty breathing; Swelling of the face, lips, tongue, or throat.

Some side effects can occur up to 30 hours after taking this medicine.

Stop using this medicine and call your doctor straight away if you:

  • severe constipation, stomach pain, or gas;
  • persistent or worsening diarrhea;
  • watery or bloody diarrhea;
  • severe pain in the upper abdomen that spreads to your back;
  • Fever, flushing (warmth, redness, or tingly feeling);
  • Hallucinations, seizure;
  • fast breathing, weak, or shallow breathing;
  • fast heart rate; or
  • Dehydration symptoms - You feel very thirsty, hot, unable to urinate, sweat profusely, or have hot and dry skin.

Common side effects can include:

will Bactrim treat a yeast infection
  • Drowsiness, dizziness, restlessness;
  • A headache;
  • Numbness in hands or feet;
  • Depression, not feeling well;
  • Confusion, feelings of extreme happiness;
  • red or swollen gums;
  • dry mouth, nose, or throat;
  • Nausea, vomiting, upset stomach, loss of appetite; or
  • Rash, dryness, or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lomotil (Diphenoxylate and Atropine)

Find out more 'Lomotil Professional Information


The following serious side effects are described elsewhere on the label:

At the therapeutic Doses of Lomotil, the following other side effects have been reported; They are listed in descending order of severity, but not frequency:

Nervous system: Numbness of the extremities, euphoria, depression, malaise / lethargy, confusion, calmness / sleepiness, dizziness, restlessness, headache, hallucinations

Allergic: Anaphylaxis, angioneurotic edema, urticaria, gum swelling, pruritus

Gastrointestinal system: Megacolon, paralytic ileus, pancreatitis, vomiting, nausea, anorexia, abdominal discomfort

The following side effects associated with atropine sulfate are listed in descending order of severity but not frequency: hyperthermia, tachycardia, urinary retention, flushing, dryness of the skin and mucous membranes.

Read full FDA prescribing information for Lomotil (Diphenoxylate and Atropine)

Read more '' Related Resources for Lomotil

Related health

Related drugs

Read the Lomotil User Reviews ยป

Enskyce is a low dose pill

Lomotil patient information is provided by Cerner Multum, Inc. and Lomotil consumer information is provided by First Databank, Inc., all of which are used under license and are subject to their respective copyrights.